Avaliação dos compostos bioativos e atividade antiparasitária do buriti (Mauritia flexuosa L.) sobre Strongyloides venezuelensis, em modelo experimental in vivo

Abstract

Strongyloidiasis is a socially and economically neglected disease caused by helminths of the genus Strongyloides spp. Strongyloides stercoralis is the parasite, among the species of the genus, that causes the disease in humans. The most used drug for the treatment of helminthiasis is ivermectin, which despite its effectiveness has shown side effects and toxicity in the organism of affected individuals, thus making it relevant to search for new therapeutic alternatives, especially in Brazilian biomes, such as thick. Therefore, the aim of this work was to characterize the bioactive compounds and evaluate the antioxidant capacity of oil and pulp compounds of buriti (Mauritia flexuosa L) and administer them in vivo on Strongyloides venezuelensis, evaluating the anthelmintic activity of the fruit. The results obtained regarding the characterization of the fruit demonstrated that both oil (9248.7 ± 315.6 µg of β-carotene/g of sample) and pulp (11215.2 ± 694.9 µg of β-carotene/g of sample), thus being a rich source of carotenoids as described in the literature. Among the fatty acids evaluated in our study, the major fatty acid was oleic acid, which is important for the regulation of the body. The results obtained regarding the antioxidant capacity demonstrate that DPPH was higher in the hydrophilic extract of buriti pulp (4368.77 ± 11.99µmol of Trolox/100g of sample). The parasitological experiment showed that both oil and pulp presented anthelmintic activity, observing an oviposition peak at 9°dpi (385 ± 15.87, pulp and 338.2 ± 21.50, oil), number of worms (16.72 ± 0.39, pulp; 8.55 ± 0.79; oil), relative increase in heart weight (0.0034 ± 0.00011, pulp; 0.0028 ± 0.00021, oil) for the group treated with pulp. Thus, we can conclude that the treatment with buriti oil had better anthelmintic potential when compared to pulp, in the S.ven infection model.