Relação entre idade, doenças crônicas não transmissíveis e estresse oxidativo em uma amostra de indivíduos de Sinop/MT

Abstract

The proportion of the world's population aged over 60 will almost double between 2015 and 2050. In Brazil, estimates indicate that the elderly population will be approximately 53 million in 2050, an increase of approximately 80% compared to the year 2017. However, a worrying factor: the lack of quality of life to enjoy the additional years of life; the increase in years of life can be related to the emergence of diseases, such as non-communicable chronic diseases, which can negatively impact the experience of these extra years of life. Identifying and understanding how these diseases, as well as their risk factors, are distributed according to age in the population, especially considering regional particularities, is a tool that can help to mitigate the loss of good health conditions with advancing age. Thus, the objective of this study was to evaluate the influence of age on the prevalence of non-transmissible chronic diseases and markers of oxidative stress in patients from Sinop/MT. A cross-sectional and descriptive study was carried out in a convenience sample (n=17) of adult Brazilian individuals of both sexes, in the city of Sinop/MT. Participants were divided into two groups according to age: adults (18 to 59 years; n=10) and elderly (over 60 years; n=7). The following variables were measured: body weight, height, body circumferences (arm, hip and abdomen) and systolic and diastolic blood pressure. In the blood, the following analyzes were performed: gamma glutamyltransferase (Gamma GT), and C-reactive protein (PCR), aspartate aminotransferase (AST), alanine aminotransferase (ALT), glucose, urea, creatinine, total cholesterol and fractions, and triacylglycerol (TG). In addition, the parameters indicative of oxidative stress in the plasma were also determined, namely: Superoxide dismutase (SOD), catalase (CAT), glutathione S transferase (GST), reduced glutathione (GSH), thiobarbituric acid reactive substances (TBARS), protein carbonylation (CARBONIL), and vitamin C (VIT C). The elderly group had an average age 57% higher than the adult group. There was no difference between the adult and elderly groups for the following variables: body weight, height, body mass index, arm circumference, hip circumference, and systolic and diastolic blood pressure. However, the elderly group showed an increase in abdominal circumference and waist-hip ratio. It was not possible to demonstrate some degree of dependence between age and blood variables, both clinical and oxidative stress, except for triacylglycerol. In conclusion, the results indicate that age causes anthropometric changes and changes in plasma levels of triacylglycerol, however, without changing blood markers of oxidative stress.