Efeitos do etabonato de loteprednol e do cetorolaco de trometamina na inflamação intraocular e no estresse oxidativo após a quebra da barreira hematoaquosa induzida por paracentese em gatos

Abstract

Objective: To compare the effects of loteprednol etobonate (LE) and ketorolac tromethamine (KT) on pupil diameter (PD) and aqueous humor levelsof prostaglandin E2 (PGE₂), total protein (TP), and glutathione (GSH) following paracentesis-induced intraocular inflammation in cats. Methods: Thirty cats (n = 10/group) underwent anterior chamber paracentesisat T1and T2 (60 minutes apart). At T1, the right eye received one drop of LE, KT, or saline(CG). PD was measured at T1 and T2, and aqueous humor samples wereanalyzedfor PGE₂, TP, and GSH. Results: At T1, PD, PGE₂, TP, and GSH levels did not differ among groups(p>0.05). At T2, PGE₂ concentrations were significantly lower in LE (p < 0.0001) and KT(p = .01) groups when compared to CG. When compared to CG, TP values were significantly lower only in the LE group (p = .002). GSH levels decreased significantly across all groups (p < 0.01) at T2, maintaining significantly higher levelsin the LE group (P = .04). At T2, PD decreased significantly in the CG(p =.003) andKT (p = .01) groups, but not in the LE group (p = .18). Conclusions: EL and CT showed a controlled increase in PGE₂ levels following paracentesis. LE also significantly decreased TP levels, mitigated miosis, and preserved GSH, indicating reduced oxidative stress. Considering that KTalsoreduced PGE₂ levels, further studies are warranted to determine whether KT might effectively reduce protein influx into the anterior chamber at later time points.