Efeitos hematológicos e bioquímicos do uso do firocoxib sobre a dose do propofol em cães

Abstract

This study aimed to evaluate the clinical, hematological and biochemical changes produced by the administration of nonsteroidal anti-inflammatory drug (NSAID) firocoxib prior to induction with propofol, in addition to correlating its influence on quality and dose on anesthetic induction. Thirty dogs from the routine of elective surgeries of the Veterinary Hospital of the Federal University of Mato Grosso (HOVET/UFMT) were used, with mean ± standard deviation, weight of 8.10 ± 5.28 kg, and age of 40.66 ± 36.16 months, clinically healthy based on clinical, hematological, and serum biochemical results. The animals were randomized into three groups, in which Group I (GI) did not receive firocoxib, Group II (GII) received a single dose (5 mg/kg), 1 hour and 30 minutes before anesthetic induction, and those of Group III (GIII) received the same dose as those of GII for 40 consecutive days, every 24 hours, prior to anesthetic induction. Induction was performed with propofol (to effect) in 0.5 mg/kg increments for 15 seconds, after which the animals were intubated and the final volume of propofol in milliliters (mL) was recorded. It was observed that the averages differed statistically in the Tukey's test (p<0.05) for erythrocytes (p=0.0044), hemoglobin (p=0.0040), hematocrit (p=0.0161) and CHGM (p=0.0369) in GII compared to GI and GIII, in albumin (p=0.0076) in GIII compared to GI and GII and in FA (p=0.0102) in GII compared to GI and GIII, However, all haematological and biochemical variables evaluated remained within the reference range for the species in question, as no clinical changes were observed during the period of administration of firocoxib. The mean ± standard error of propofol in mg/kg was 6.59 ± 0.49; 6.10 ± 0.47 and 7.82 ± 0.75 for GI, GII and GIII, respectively, and all animals obtained the good criterion for the quality of induction. It can be concluded that the single or prolonged use of this NSAID did not cause adverse effects in the animals, however, they produced slight changes in hematological and biochemical variables, which caused an increase in the dose of propofol to be used at the time of GIII anesthetic induction. Therefore, medical therapy instituted with this NSAID in a single or prolonged manner should be considered at the time of anesthetic induction with propofol in dogs.