Estudo da associação do polimorfismo rs7903146 do gene TCF7L2 com a doença hepática gordurosa não alcoólica em mulheres obesas e diabéticas

Abstract

Introduction: Single nucleotide polymorphisms (SNPs) in TCF7L2 have been reported as possible risk factors for NAFLD and a number of metabolic disorders involving glucose homeostasis and lipoproteins. Method: We investigate the association between rs7903146 TCF7L2 gene polymorphism and NAFLD diabetic obese women. According to liver steatosis they were divided in NAFLD and Non-NAFLD. Results: The NAFLD group had higher waist circumference, body fat percentage, fasting and postprandial insulin, HOMA-β, triacylglycerols, ALT, AST, GGT, alkaline phosphatase and TNF-α compared to Non-NAFLD group. QUICKI, HDL, adiponectin and interleukin-6 were lower in NAFLD patients. No association was observed between rs7903146 polymorphism and NAFLD when analyzed isolated, but there was an interaction when this polymorphism was related with NAFLD and diabetes on the following parameters: fasting insulin, HOMA-β, QUICKI, triacylglycerols and TNF-α. The subcutaneous/visceral fat ratio was lower in patients NAFLD diabetics with TT genotype. There was a negative correlation between subcutaneous/visceral fat ratio and plasma triacylglycerols in individuals with at least one T allele. Conclusion: These results demonstrate that TCF7L2 rs7903146 polymorphism can influence some risk factors that predispose to NAFLD in diabetic obese women related to an increased lipid serum and visceral fat accumulation.