Avaliação da viabilidade celular, toxicidade aguda e subaguda do óleo da Attalea phalerata Mart. ex Spreng (Acuri) padronizado em β-caroteno

Abstract

In Brazil, there is Attalea phalerata Mart. ex Spreng, a species found from Acre to São Paulo, being part of the composition of different forest formations. In general, it is mentioned as occurring in Semi-deciduous Latifoliate Forests, on the edges of groves and in fields. Objective: to evaluate the toxic effects of A. phalerata oil in an in vitro and in vivo model standardized in β - carotene. Among the concentrations evaluated, it was possible to show that, after 24 hours of treatment, the dose of 200 µg/mL promoted a 14.1% reduction in cell viability. With the exception of the 12.5 µg/mL dose, which reduced viability by 6.5%, none of the concentrations below 100 µg/mL were able to inhibit cell viability. However, they showed viability greater than 100%, suggesting that the oil can contribute to cell growth. The average final weight of the MT1 and MT2 groups was approximately 16% lower than the control group and the average feed consumption of the Male Treated 1 (MT1) group was approximately 15% lower than that of the control group and the Male Treated 2 (MT2) group was approximately 7% higher than that of the than the MT1 group. The data presented of A. phalerata oil standardized in β-carotene did not cause death in the animals, although some signs of toxicity were observed in the Hippocratic test in males. Toxicity effects were not observed in females in the Hippocratic test, as well as in the subacute test, thus suggesting that A. phalerata oil can be used for biological and pharmacological investigation.