Selenoacetilenos promovem proteção contra paralisia induzida por Aβ e longevidade em Caenorhabditis elegans

Abstract

Alzheimer's disease (AD) is an age-related neurodegenerative disease, mainly characterized by the accumulation of extracellular plaques of amyloid beta peptide (Aβ). In this study, we report the protective effect of a series of selenoacetylenes newly synthesized in Caenorhabditis elegans CL4176 and the toxicity of these compounds for different non-target organisms. The results showed that C. elegans CL4176 treated with selenoacetylenes 1f 0.21mM and 1e 0.27mM exhibited remarkably reduced paralysis suggesting potential in vivo protection against Aβ toxicity, even in comparison with the positive control (Galantamina®). In addition, selenoacetylenes 1f 0.42mM and 1h 0.42mM increased the life expectancy of C. elegans BA17 by 53.19% compared to the untreated group, and the treatment of C. elegans N2 with selenoacetylenes 1e, 1f and 1h promoted an increase in the life of 43% of the worms under conditions of oxidative stress and 33% under conditions of thermal stress in relation to the untreated groups. In conclusion, the results suggest that selenoacetylenes may protect against Aβ-induced toxicity by inhibiting Aβ aggregation, increasing resistance to acute stress and consequent modulation of longevity in C. elegans, which together favor metabolic homeostasis.