Efeitos sistêmicos da instilação ocular de cetorolaco de trometamol a 0,4% por 15 dias em gatos saudáveis

Abstract

Purpose: to assess the impact of thrice-daily instillation of trometamol ketorolac (TK) over a 15-day period on the blood count, serum biochemistry profile, urinalysis parameters, bleeding time (BT), and fecal occult blood test (FOB) in healthy cats. Methods: blood was collected from 15 healthy cats to assess hematological and serum biochemical parameters at baseline and 15 days after the instillation of KT three times a day. Urinalysis parameters, the presence of FOB, and BT were also assessed at the same time points. Results: baseline blood count, serum biochemical, and urinary values were within reference limits. On day 15, significant reductions were observed in the hematocrit (p = .03), total protein (p = 0.02), and potassium (p = 0.004) compared to baseline values. Despite these changes, all measurements remained within the reference limits, except for ALT, which significantly increased when compared to baseline values (p = 0.01). The BT assessed at baseline (133.5 ± 61.33 sec.) was significantly longer than that recorded on day 15 (102.1 ± 32.76 sec.) (p = 0.03). At baseline, all 15 samples from cats tested negative for FOB (Figure 1A). However, by day 15, 11 out of 15 samples tested positive for FOB (p < 0.0001). Conclusion: the current study showed that in healthy cats, the thrice-daily instillation of KT for 15 consecutive days induced hepatocellular injury and gastrointestinal bleeding, with potential repercussions on hematocrit, total protein, and potassium levels. However, our results must be interpreted with caution, as a control group is lacking in the present study.