Síntese, caracterização e avaliação biológica para os compostos de coordenação de rutênio (II) e rutênio (III) utilizando o ligante N-(3-piridil)-isonicotinamida

Abstract

In this sense, the present work has as main objective to synthesize and characterize ruthenium (II) and (III) compounds, coordinated to the N- (3-pyridyl) -isonicotinamide (3-pina) ligand. Thus, new compounds have been formed they are; C1 [Ru(Cl)3(H2O)2(3-pina).5H2O, C2 [Ru(Cl)2(H2O)3(3-pina)]Cl.1/2H2O and C3 [RuCl(NH3)(H2O)2(3-pina)](BF4).1/2H2O. The characterizations of these compounds were performed by thermoanalytical analyzes TG-DTG and TG-DSC, the data obtained in the TG-DTG analysis shows that the compound C1 undergoes mass loss in three stages, corresponding to the oxidative degradation process of the ligand (3- pina) up to 900 ° C with the formation of the RuO2 residue with an error of 0.377% (Exp. = 64.431%; Calc. = 64.094%). And for C2, it undergoes mass loss in five stages up to 900 ° C also with the formation of the RuO2 residue with an error of 0.584% (Exp. = 71.080%; Calc. = 71.660%). As for the C3 compound, it undergoes mass loss in six stages up to 900 ° C with the formation of the RuO2 residue with an error of 0.926% (TG / exp = 74.451%; Calc = 73.525%). The FTIRmed analysis reveals for both compounds C1, C2 and C3, a band of 1684cm-1 , 1743cm-1

, 1679 cm-1

respectively, section ʋ(C=O) characteristic of the free ligand

(1678cm-1 ). The analysis of the UV-Vis spectra showed that the compounds formed C1, C2 and C3 showed bands close to that of the free ligand at 270 nm. At 209 nm and 262 nm for C1 and at 235 nm and 268 nm for C2. As for C3, it showed absorption at 264 nm where there was a shift to regions of greater energy. From the characterizations it was possible to propose biological applications for compounds C2 and C3. For the C1 compound, it was not possible due to its insolubility in water. It was analyzed in the compounds and in the free ligand, their cell viability, where it was possible to observe that all of them do not present toxicity against the peripheral blood mononuclear cells. Its microbicidal and phagocytic activities were tested for the bacteria Staphylococcus aureus (Gram positive) and Escherichia coli (Gram negative), the results showed that ruthenium compounds have great potential as an antimicrobial and phagocytic agent.